Abstract
This study investigated the differences in serum brain-derived neurotrophic factor (BDNF) levels between children and adolescents with autism spectrum disorders (ASD) and intellectual disability (ID). BDNF is a protein that plays a crucial role in neuronal growth and development.
Methods
The study involved 51 children and adolescents with ASD, 46 children and adolescents with ID, and 48 typically developing children as a control group. Serum BDNF levels were measured using an enzyme-linked immunosorbent assay (ELISA).
Results
The study found that children with ASD had significantly higher levels of mature BDNF (mBDNF) compared to children with ID and typically developing children. Additionally, the ratio of mBDNF to its precursor proBDNF was lower in children with ASD compared to the other groups.
Discussion
These findings suggest that BDNF levels may be a potential biomarker for differentiating between ASD and ID. However, further research is needed to confirm these findings and to elucidate the underlying mechanisms.
Conclusion
This study provides preliminary evidence that BDNF levels may differ between children and adolescents with ASD and ID. Further research is needed to determine the clinical utility of BDNF as a biomarker for ASD.
FAQ
Q1: What is brain-derived neurotrophic factor (BDNF)?
A: Brain-derived neurotrophic factor (BDNF) is a protein that plays a crucial role in the growth, development, and maintenance of neurons in the brain.
Q2: What are the forms of BDNF in the human brain?
A: There are two forms of BDNF in the human brain: the BDNF precursor (proBDNF) and mature BDNF (mBDNF)
Q3: What is the significance of altered BDNF levels in ASD and ID?
A: Altered BDNF levels have been associated with various neurological and psychiatric disorders, including ASD and ID. This study found that the serum BDNF levels were significantly lower in children and adolescents with ASD compared to those with ID.
Source:
https://www.sciencedirect.com/science/article/abs/pii/S0022395624000013